Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC015
Sex MALE
Dominant hand LEFT
Test date and time 2022-03-18 13:58
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 1/2+1/4+1/2+1/4 tbl Sermion 1 uvece

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 21, 'TP': 18, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 14, 'TP': 24, 'FP': 16}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 22, 'TN': 12, 'TP': 20, 'FP': 18}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.956
timePerCircleCoV 0.210176
timePerCircleSlope 0.00867792
meanError 2.13881
tremorFreq 5.27344
tremorRelPower 28.1826
tremorGyroAmpMean 0.0150042
tremorGyroAmpSlope -0.00198107
tremorGyroAmpCoV 0.31004
tremorCoordAmpMean 0.0879803
tremorCoordAmpSlope -0.00208757
tremorCoordAmpCoV 0.840373
tremorAccAmpMean 0.0337324
tremorAccAmpSlope 0.00483571
tremorAccAmpCoV 0.320784
tremorPcRelVar 0.60475
tremorPcX -0.714319
tremorPcY -0.69982

Circle Segment 1

Duration 7.8 s, Accuracy Estimate 1.974 (lower is better)

Circle Segment 2

Duration 5.16 s, Accuracy Estimate 2.288 (lower is better)

Circle Segment 3

Duration 5.4 s, Accuracy Estimate 2.19 (lower is better)

Circle Segment 4

Duration 6.64 s, Accuracy Estimate 2.291 (lower is better)

Circle Segment 5

Duration 8.4 s, Accuracy Estimate 1.914 (lower is better)

Circle Segment 6

Duration 6.36 s, Accuracy Estimate 2.332 (lower is better)

Circle Segment 7

Duration 9.64 s, Accuracy Estimate 2.134 (lower is better)

Circle Segment 8

Duration 7.8 s, Accuracy Estimate 1.92 (lower is better)

Circle Segment 9

Duration 6.96 s, Accuracy Estimate 2.051 (lower is better)

Circle Segment 10

Duration 5.4 s, Accuracy Estimate 2.295 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 25.832
timePerSpiralCoV 0.158935
timePerSpiralSlope 0.0205899
meanError 2.10777
tremorFreq 5.76172
tremorRelPower 29.7487
tremorGyroAmpMean 0.0134903
tremorGyroAmpSlope 0.000403575
tremorGyroAmpCoV 0.336749
tremorCoordAmpMean 0.0659035
tremorCoordAmpSlope 0.00136942
tremorCoordAmpCoV 0.810388
tremorAccAmpMean 0.0904131
tremorAccAmpSlope 1.85101e-05
tremorAccAmpCoV 0.110505
tremorPcRelVar 0.55776
tremorPcX 0.81767
tremorPcY -0.575688

Spiral Segment 1

Duration 20.4 s, Accuracy Estimate 2.496 (lower is better)

Spiral Segment 2

Duration 23.92 s, Accuracy Estimate 2.149 (lower is better)

Spiral Segment 3

Duration 24.84 s, Accuracy Estimate 2.014 (lower is better)

Spiral Segment 4

Duration 24.52 s, Accuracy Estimate 1.963 (lower is better)

Spiral Segment 5

Duration 27.08 s, Accuracy Estimate 2.065 (lower is better)

Spiral Segment 6

Duration 28.48 s, Accuracy Estimate 2.08 (lower is better)

Spiral Segment 7

Duration 33.52 s, Accuracy Estimate 1.936 (lower is better)

Spiral Segment 8

Duration 26.44 s, Accuracy Estimate 2.289 (lower is better)

Spiral Segment 9

Duration 19.84 s, Accuracy Estimate 2.12 (lower is better)

Spiral Segment 10

Duration 29.28 s, Accuracy Estimate 1.965 (lower is better)

Elel

eDurationMean 0.690303
eDurationStd 0.256332
eDurationStdnorm 0.371333
eDurationMedian 0.66
eDurationQuartdelta 0.2175
eDurationQuartdeltanorm 0.329545
eDurationKurt 4.14876
eDurationTrenddiff -0.055
eDurationTrendratio 0.918819
eWidthMean 8.60695
eWidthStd 2.81119
eWidthStdnorm 0.326619
eWidthMedian 8.44877
eWidthQuartdelta 3.1005
eWidthQuartdeltanorm 0.366977
eWidthKurt 3.57499
eWidthTrenddiff 0.659647
eWidthTrendratio 1.08187
eHeightMean 17.655
eHeightStd 4.99473
eHeightStdnorm 0.282908
eHeightMedian 18.369
eHeightQuartdelta 5.12149
eHeightQuartdeltanorm 0.278811
eHeightKurt 4.78951
eHeightTrenddiff -3.02656
eHeightTrendratio 0.84636
eAspectMean 0.502045
eAspectStd 0.139949
eAspectStdnorm 0.278757
eAspectMedian 0.504832
eAspectQuartdelta 0.244491
eAspectQuartdeltanorm 0.484301
eAspectKurt 2.19666
eAspectTrenddiff 0.126691
eAspectTrendratio 1.3123
eSlantMean -0.15844
eSlantStd 0.150906
eSlantStdnorm -0.952449
eSlantMedian -0.182692
eSlantQuartdelta 0.242029
eSlantQuartdeltanorm -1.32479
eSlantKurt 2.28118
eSlantTrenddiff -0.00269678
eRtopMean 0.596917
eRtopStd 0.158566
eRtopStdnorm 0.265642
eRtopMedian 0.600977
eRtopQuartdelta 0.199412
eRtopQuartdeltanorm 0.331813
eRtopKurt 3.06965
eRtopTrenddiff -0.0166622
eRbotMean 0.949706
eRbotStd 0.283824
eRbotStdnorm 0.298854
eRbotMedian 0.880541
eRbotQuartdelta 0.480677
eRbotQuartdeltanorm 0.545889
eRbotKurt 2.22832
eRbotTrenddiff -0.0967282
eRrightMean 0.760758
eRrightStd 0.146138
eRrightStdnorm 0.192096
eRrightMedian 0.79474
eRrightQuartdelta 0.135357
eRrightQuartdeltanorm 0.170316
eRrightKurt 15.587
eRrightTrenddiff -0.0103482
eRleftMean 0.530245
eRleftStd 0.117294
eRleftStdnorm 0.221207
eRleftMedian 0.500939
eRleftQuartdelta 0.111098
eRleftQuartdeltanorm 0.221779
eRleftKurt 3.06934
eRleftTrenddiff -0.0338167
lDurationMean 0.827791
lDurationStd 0.277431
lDurationStdnorm 0.335147
lDurationMedian 0.78
lDurationQuartdelta 0.23375
lDurationQuartdeltanorm 0.299679
lDurationKurt 5.56326
lDurationTrenddiff -0.18
lDurationTrendratio 0.789474
lWidthMean 9.5402
lWidthStd 3.13271
lWidthStdnorm 0.328369
lWidthMedian 9.29802
lWidthQuartdelta 3.4515
lWidthQuartdeltanorm 0.371208
lWidthKurt 5.20001
lWidthTrenddiff 0.92349
lWidthTrendratio 1.10812
lHeightMean 33.3153
lHeightStd 6.76422
lHeightStdnorm 0.203037
lHeightMedian 34.047
lHeightQuartdelta 9.68626
lHeightQuartdeltanorm 0.284497
lHeightKurt 2.57608
lHeightTrenddiff -7.02
lHeightTrendratio 0.805825
lAspectMean 0.301747
lAspectStd 0.122233
lAspectStdnorm 0.405085
lAspectMedian 0.277969
lAspectQuartdelta 0.156215
lAspectQuartdeltanorm 0.561986
lAspectKurt 2.95197
lAspectTrenddiff 0.111016
lAspectTrendratio 1.50587
lSlantMean -0.12172
lSlantStd 0.0959166
lSlantStdnorm -0.788007
lSlantMedian -0.107233
lSlantQuartdelta 0.110507
lSlantQuartdeltanorm -1.03053
lSlantKurt 2.68716
lSlantTrenddiff 0.0157102
lRtopMean 0.5714
lRtopStd 0.161457
lRtopStdnorm 0.282565
lRtopMedian 0.592577
lRtopQuartdelta 0.22752
lRtopQuartdeltanorm 0.383951
lRtopKurt 2.16468
lRtopTrenddiff -0.0169003
lRbotMean 1.07421
lRbotStd 0.378088
lRbotStdnorm 0.35197
lRbotMedian 1.02597
lRbotQuartdelta 0.472741
lRbotQuartdeltanorm 0.460773
lRbotKurt 3.56501
lRbotTrenddiff -0.217691
lRrightMean 0.775508
lRrightStd 0.120764
lRrightStdnorm 0.155723
lRrightMedian 0.813216
lRrightQuartdelta 0.178862
lRrightQuartdeltanorm 0.219944
lRrightKurt 3.17892
lRrightTrenddiff -0.0137127
lRleftMean 0.577617
lRleftStd 0.170256
lRleftStdnorm 0.294756
lRleftMedian 0.560644
lRleftQuartdelta 0.206268
lRleftQuartdeltanorm 0.367913
lRleftKurt 2.47042
lRleftTrenddiff -0.0481524

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.856841
sumTouchScores 15.4231
meanMovementTime 0.923824
numTouches 18
undershootPercentage 0
overshootPercentage 11.1111

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.945611
sumTouchScores 10.4017
meanMovementTime 1.3095
numTouches 11
undershootPercentage 0
overshootPercentage 9.09091

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 18.872
timePerZigzagCoV 0.176543
timePerZigzagSlope 0.103222
meanError 2.07353
tremorFreq 5.76172
tremorRelPower 24.3384
tremorGyroAmpMean 0.0222778
tremorGyroAmpSlope -0.00592937
tremorGyroAmpCoV 0.323826
tremorCoordAmpMean 0.128125
tremorCoordAmpSlope -0.0166656
tremorCoordAmpCoV 0.789993
tremorAccAmpMean 0.0977799
tremorAccAmpSlope -0.000603938
tremorAccAmpCoV 0.0766703
tremorPcRelVar 0.825909
tremorPcX 0.265107
tremorPcY 0.964219

ZigZag Segment 1

Duration 15.52 s, Accuracy Estimate 2.035 (lower is better)

ZigZag Segment 2

Duration 15.24 s, Accuracy Estimate 2.244 (lower is better)

ZigZag Segment 3

Duration 19.64 s, Accuracy Estimate 1.959 (lower is better)

ZigZag Segment 4

Duration 22.16 s, Accuracy Estimate 2.151 (lower is better)

ZigZag Segment 5

Duration 21.8 s, Accuracy Estimate 1.978 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.8
timePerZigzagCoV 0.131988
timePerZigzagSlope -0.0826087
zigzagHeightMean 69.1845
zigzagHeightCoV 0.110386
zigzagHeightSlope -0.047843
meanError 0.0430381
tremorFreq 5.66406
tremorRelPower 29.0346
tremorGyroAmpMean 0.0340642
tremorGyroAmpSlope 0.00505298
tremorGyroAmpCoV 0.312008
tremorCoordAmpMean 0.146072
tremorCoordAmpSlope 0.0146752
tremorCoordAmpCoV 1.00205
tremorAccAmpMean 0.10677
tremorAccAmpSlope 0.000848361
tremorAccAmpCoV 0.190351
tremorPcRelVar 0.891175
tremorPcX -0.161516
tremorPcY -0.98687

ZigZag Offset Segment 1

Duration 15.8 s, Accuracy Estimate 0.073 (lower is better)

ZigZag Offset Segment 2

Duration 15.36 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 3

Duration 13.8 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 4

Duration 12.52 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 11.52 s, Accuracy Estimate 0.058 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.66}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.6149337103497987}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9270945892666871}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.602357651694645}